Translational research in audiology, neurotology, and the hearing sciences / Colleen G. Le Prell ... [and more], editors.

Format
Book
Language
English
Published/​Created
Cham : Springer, 2016.
Description
1 online resource (275 pages).

Availability

Available Online

Details

Subject(s)
Series
  • Springer handbook of auditory research [More in this series]
  • Springer Handbook of Auditory Research ; v. 58
Summary note
Translational Research is the interface between basic science and human clinical application, including the entire process from animal studies to human clinical trials (phases I, II, and III). Translational Research moves promising basic science results from the laboratory to bedside application. Yet, this transition is often the least-defined, least-understood part of the research process. Most scientific training programs provide little or no systematic introduction to the issues, challenges, and obstacles that prevent effective research translation, even though these are the key steps that enable high-impact basic science to ultimately result in significant clinical advances that improve patient outcome. This volume will provide an overview of key issues in translation of research from "bedside to bench to bedside", not only from the perspective of the key funding agencies, but also from the scientists and clinicians who are currently involved in the translational research process. It will attempt to offer insight into real-world experience with intellectual property and technology transfer activities that can help move auditory technologies ahead, as scientists and clinicians typically have little or no formal training in these areas. Translational Research in Audiology and the Hearing Sciences will be aimed at graduate students and postdoctoral investigators, as well as professionals and academics. It is intended to function as a high-profile and up-to-date reference work on Translational Research in the auditory sciences, emphasizing research programs in the traditional areas including drugs and devices, as well as less traditional, still emerging, areas such as sensorineural hearing loss, auditory processing disorder, cochlear implants and hearing aids, and tinnitus therapies.
Notes
5 Development of Drugs for Noise-Induced Hearing Loss.
Source of description
Print version record.
Contents
  • Acoustical Society of America; Series Preface; Preface 1992; Volume Preface; Contents; Contributors; 1 Perspectives on Auditory Translational Research; Abstract; 1.1 Introduction to the Volume; 1.2 Clinical and Translational Research; 1.3 Translational Efforts Reviewed in This Volume; 1.3.1 The Scientific Continuum and Challenges in Translational Research; 1.3.2 Diagnosis and Treatment of Central Auditory Processing Disorder; 1.3.3 Sudden Hearing Loss; 1.3.4 Noise-Induced Hearing Loss; 1.3.5 Cisplatin-Induced Hearing Loss; 1.3.6 Drugs for Treatment of Tinnitus.
  • 1.3.7 A Molecular Therapeutic for Restoration of Auditory Function1.3.8 Cochlear Implants/Infrared Neural Stimulation; 1.4 Summary; References; 2 Current Issues in Clinical and Translational Research in the Hearing Sciences, Audiology, and Otolaryngology; Abstract; 2.1 Translational Research; 2.2 Translational Research in Hearing and Balance; 2.3 The Translational Science Spectrum; 2.3.1 Basic Science; 2.3.2 Preclinical Research; 2.3.3 Clinical Research; 2.3.4 Clinical Implementation; 2.3.5 Public Health; 2.4 Evidence-Based Practice; 2.4.1 Levels of Evidence.
  • 2.4.2 Statistical Significance Versus Clinical Significance2.4.3 The Gap Between Knowledge and Action; 2.5 Technology Transfer and the Valley of Death; 2.5.1 Disclosure; 2.5.2 Patents; 2.5.2.1 Patents for Drugs That Mediate Auditory Trauma; 2.5.3 Marketing, Negotiating, and Licensing; 2.6 Summary; 2.7 Closing Comments; Acknowledgments; References; 3 Auditory Processing Disorder: Biological Basis and Treatment Efficacy; Abstract; 3.1 Introduction; 3.2 cABR: Objective Assessment of Central Auditory Function; 3.3 Integrating the cABR into Clinical Practice.
  • 3.4 Evaluation of APD and Auditory-Based Learning Impairments3.5 Treatment of APD and Auditory-Based Learning Impairments; 3.6 Aging Effects on Auditory Processing: Spotlight on Hearing in Noise; 3.7 Treatment of Auditory Processing and Speech-in-Noise Perception Deficits in Older Adults; 3.8 Challenges: Evaluating Training Efficacy in Real-World Environments; 3.9 Future Directions; 3.10 Summary; Acknowledgments; References; 4 Sudden Sensorineural Hearing Loss; Abstract; 4.1 Introduction; 4.1.1 Basic Science of SSNHL; 4.1.2 Epidemiology of SSNHL; 4.2 Clinical Presentation.
  • 4.2.1 Autoimmune Inner Ear Disease and SSNHL4.2.2 Etiology of Idiopathic SSNHL; 4.2.3 Membranous Breaks; 4.2.4 Viral Infection; 4.2.5 Vascular Occlusion; 4.2.6 Autoimmune Mechanisms; 4.2.7 Cellular Stress Response; 4.3 Prognosis; 4.3.1 Risk Factors; 4.4 Diagnostics and Evaluation; 4.4.1 History and Physical; 4.4.2 Laboratory Testing; 4.4.3 Imaging; 4.5 Treatment; 4.5.1 Steroids; 4.5.2 Hyperbaric Oxygen; 4.5.3 Other Pharmacologic Therapy; 4.5.4 Salvage Therapy; 4.5.5 Counseling and Amplification; 4.5.6 Clinical and Experimental Significance; 4.6 Summary; References.
ISBN
  • 9783319408484 ((electronic bk.))
  • 3319408488 ((electronic bk.))
  • 3319408461
  • 9783319408460
OCLC
961449339
Doi
  • 10.1007/978-3-319-40848-4
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