Details

Subject(s)

• Tissue engineering [Browse]
• Nerve tissue—Cultures and culture media [Browse]
• Stem cells—Therapeutic use [Browse]
• Nerve tissue [Browse]
• Stem cells [Browse]

Summary note

Engineering Neural Tissue from Stem Cells covers the basic knowledge needed to understand the nervous system and how existing cells can be used to create neural tissue. This book presents a broad range of topics related to the design requirements for engineering neural tissue from stem cells. It begins with the anatomy and function of the central and peripheral nervous system, also covering stem cells, their relation to the nervous system and their function in recovery after injury or disease. In addition, the book explores the role of the extracellular matrix and vasculature/immune system and biomaterials, including their suitability for neural tissue engineering applications.

Bibliographic references

Includes bibliographical references and index.

Contents

• Ch. 1 The Need for Engineering Neural Tissue Using Stem Cells
• 1. Overview of the Nervous System
• 2. Demand for Cures for Neurodegenerative Diseases and Disorders Using Neural Tissue Engineering
• 2.1. Alzheimer's Disease
• 2.2. Parkinson's Disease
• 2.3. Huntington's Disease
• 2.4. Amyotrophic Lateral Sclerosis
• 2.5. Multiple Sclerosis
• 2.6. Traumatic Brain Injury
• 2.7. Traumatic Spinal Cord Injury
• 3. The Discovery of Stem Cells and Their Impact on Tissue Engineering
• 4. The Need for Interdisciplinary Approaches for Treating Neurological Disorders
• Relevant Websites
• References
• ch. 2 Introduction to the Nervous System
• 1. Introduction
• 2. The Structure and Function of the Central Nervous System
• 2.1. Brain
• 2.2. Spinal Cord
• 3. Peripheral Nervous System
• 4. Cells of the Nervous System
• 4.1. Neurons
• 4.2. Oligodendrocytes
• 4.3. Astrocytes
• 4.4. Schwann Cells
• 4.5. Other Cells of the Nervous System
• 5. Conclusions
• Additional Resources
• ch. 3 Stem Cells and Their Applications in Repairing the Damaged Nervous System
• 2. Discovery of Bone Marrow Stem Cells, Their Role in Nervous System, and Their Potential Applications in Treating the Damaged Nervous System
• 2.1. Discovery of Bone Marrow Stem Cells and Their Role in the Body
• 2.2. Application of Mesenchymal Stem Cell Therapies for Applications in the Nervous System
• 3. Discovery of Neural Stem Cells and Their Applications for Nervous System Repair
• 4. Derivation of Human Embryonic Stem Cells and Their Applications for Nervous System Repair
• 5. Derivation of Induced Pluripotent Stem Cells and Their Applications for Nervous System Repair
• 6. Direct Reprogramming of Mature Cells Into Functional Neural Cells
• 7. Concluding Remarks on Stem Cells and Their Potential as Cell Therapies
• Relevant Resources
• ch. 4 Design Considerations When Engineering Neural Tissue From Stem Cells
• 2. Chemical Properties of Neural Tissue
• 2.1. Proteins of the Extracellular Matrix and Their Function
• 2.2. Polysaccharides Found in the Extracellular Matrix and Their Function
• 2.3. Composition of the Extracellular Matrix of the Brain and the Spinal Cord
• 2.4. Composition of the Extracellular Matrix in the Peripheral Nervous System
• 2.5. Role of Growth Factors in the Extracellular Matrix
• 2.6. The Role of Small Molecules in Neuronal Development
• 3. Mechanical Properties of Neural Tissue
• 3.1. The Physical Topography of the Extracellular Matrix and Its Effect on Cellular Behavior
• 3.2. The Mechanical Properties of Neural Tissue and How They Relate to Stem Cell Behavior
• 4. Implications for Design of Biomaterial Scaffolds
• ch. 5 Natural Biomaterials for Engineering Neural Tissue From Stem Cells
• 2. Pure Biomaterials
• 2.1. Proteins
• 2.2. Polysaccharides
• 2.3. Mixtures of the Different Natural Extracellular Matrix Components as Scaffolds for Controlling Stem Cell Behavior for Neural Tissue Engineering Applications
• 3. Decellularized Biomaterials
• 4. Future Directions
• ch. 6 Synthetic Biomaterials for Engineering Neural Tissue From Stem Cells
• 2. Types of Synthetic Scaffolds
• 2.1. Poly (Ethylene Glycol/Poly (Ethylene Oxide)
• 2.2. Poly (Glycolic Acid)/Poly (Lactic Acid)/Poly (Lactic-co-glycolic Acid)
• 2.3. Poly (Caprolactone)
• 2.4. Poly (2-Hydroxyethyl Methacrylate)
• 2.5. Polypyrrole
• 2.6. Poly(dimethylsiloxane)
• 2.7. Self-Assembling Peptides
• 2.8. Other Potential Polymers Suitable for Applications in Neural Tissue Engineering Using Stem Cells
• 3. The Development of "Smart" Biomaterials That Respond to Stimuli
• ch. 7 Drug Delivery Systems for Engineering Neural Tissue
• 2. Diffusion-Based Drug Delivery Systems
• 2.1. Hydrogels
• 2.2. Microparticles
• 2.3. Nanoparticles
• 2.4. Microfibers
• 2.5. Nanofibers
• 3. Affinity-Based Drug Delivery Systems
• 3.1. Heparin-Based Drug Delivery Systems
• 3.2. Other Types of Affinity-Based Drug Delivery Systems
• 4. Immobilization-Based Drug Delivery Systems
• 5. Electrically Controlled Drug Delivery Systems
• 6. Optically Controlled Drug Delivery Systems
• 7. Future Directions
• ch. 8 New Technologies for Engineering Neural Tissue From Stem Cells
• 1. Introduction to New Technologies for Engineering Neural Tissues From Stem Cells
• 2. Generation of Neural Organoids From Stem Cells
• 3. The Use of 3D Bioprinting to Produce on Demand Neural Tissues
• 4. In Vitro and In Vivo Engineering of Neural Tissue From Somatic Cells
• 5. Genome Editing for Engineering Neural Tissue
• 6. Optogenetics and Designer Receptors Exclusively Activated by Designer Drugs (DREADDs)
• 7. Conclusions
• References.

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ISBN

• 9780128113851 ((paperback))
• 0128113855 ((paperback))

LCCN

2017448940

OCLC

983822603

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