Development of vaccines : from discovery to clinical testing / edited by Manmohan Singh, Indresh K. Srivasta.

Format
Book
Language
English
Published/​Created
Hoboken, N.J. : John Wiley & Sons, ©2011.
Description
xiii, 454 pages : illustrations (some color) ; 25 cm

Availability

Copies in the Library

Location Call Number Status Location Service Notes
Lewis Library - Stacks QR189 .D48 2011 Browse related items Request

    Details

    Subject(s)
    Summary note
    This book outlines the critical steps, and analytical tools and techniques, needed to take a vaccine from discovery through a successful clinical trial. Contributions from leading experts in the critical areas of vaccine expression, purification, formulation, pre-clinical testing and regulatory submissions make this book an authoritative collection of issues, challenges and solutions for progressing a biologic drug formulation from its early stage of discovery into its final clinical testing. A section with details and real-life experiences of toxicology testing and regulatory filing for vaccines is also included.
    Bibliographic references
    Includes bibliographical references and index.
    Contents
    • Microbial vaccines design : the reverse vaccinology approach / Roberto Rosini, Michele A. Barocchi, Rino Rappuoli
    • Design and development of recombinant vaccines with viral properties / Gerd Lipowsky, Martin F. Bachmann
    • Tools for vaccine design : prediction and validation of highly immunogenic and conserved class II epitopes, and development of epitope-driven vaccines / Anne S. De Groot ... [et al.]
    • Virus like-particle vaccines advantages and challenges / Ted M. Ross ... [et al.]
    • Design platforms of nanocapsules for human therapeutics or vaccines / Masaaki Kawano ... [et al.]
    • Designing immunogens for vaccine development in reference to HIV / Aemro Kassa ... [et al.] --
    • Expression and purification of recombinant proteins for vaccine applications / Carlo Zambonelli, Deeann Martinez-Guzmann, and Indresh K. Srivastava
    • DNA vaccines for infectious diesase / Samuel Stepenson, Manmohan Singh, Indresh K. Srivastava
    • Developing stable cell lines for the production of vaccine antigens / Xiaotian Zhong ... [et al.]
    • Spectroscopy of vaccines / C. Russell Middaugh, Sangeeta B. Joshi
    • Biophysical characterization of protein antigens within vaccine formulations / Padima Malyala, Derek O'Hagan, Manmohan Singh
    • Structural characteristics predict the stability of HIV / Zohar Biron ... [et al.]
    • Selection of optimal adjuvants and product factors that affect vaccine immunogenicity / Wei Wang, Manmohan Singh
    • Lyophilization and stabilization of vaccines / James Chesko ... [et al.]
    • Effect of buffers and stabilizers on vaccine stability and efficacy / Shireesh P. Apte, Sydney Ugwu
    • Selection of final product containers / Luis Baez, Adrian Distler
    • From the lab to the clinic : filing a phase I IND for an investigational vaccine / Kenneth G. Surowitz.
    ISBN
    • 9780470256374 ((cloth))
    • 0470256370 ((cloth))
    • 9781118023648 ((oBook))
    • 1118023641 ((oBook))
    • 9781118023624 ((ePDF))
    • 1118023625 ((ePDF))
    • 9781118023631 ((ePub))
    • 1118023633 ((ePub))
    LCCN
    2010048282
    OCLC
    682072290
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