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The antibody molecule : from antitoxins to therapeutic antibodies / by Anthony R. Rees.
Author
Rees, Anthony R.
[Browse]
Format
Book
Language
English
Εdition
First edition.
Published/Created
Oxford : Oxford University Press, 2015.
Description
xii, 364 pages : illustrations, portraits ; 25 cm.
Availability
Copies in the Library
Location
Call Number
Status
Location Service
Notes
Firestone Library - Stacks
QR186.7 .R44 2015
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Details
Subject(s)
Immunoglobulins
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Immunology
—
History
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Series
Oxford medical histories
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Summary note
The Antibody Molecule follows the extraordinary journey of the medics and scientists who shaped the course of medical advances in the field of immunology. One of the oldest of the medical sciences, immunology has a history that has seen chemists, physicists, and biologists alike seeking to unravel the most complex system in the human body outside the brain. This book charts its intriguing history, from the genetic basis of antibody diversity, through the understanding of the mechanism by which the immune system's first line of defence works, to breakthroughs in crystallography and the exploitation of immunoglobulins as therapeutic platforms to treat cancer, inflammation, and allergy. Tracing the developments in molecular immunology in chronological order, Professor Anthony R. Rees presents the historical contexts of the periods in rich detail, bringing them to life with quotes and illustrations. This fascinating book examines the literature of the time, turning points, and controversies. A must read for immunologists and life scientists, as well as historians of science and medicine. Book jacket.
Bibliographic references
Includes bibliographical references and index.
Contents
Antibody pre-history: the emergence of empirical immunology
Pre-molecular immunology: the dawn of mechanism
Structural chemistry: locks, keys, and colloids
The foundations of antibody-antigen recognition emerge
The cellular reformation
The molecular path unfolds
Uncovering the origins of antibody diversity
Immunoglobulin constant regions
Effector functions of constant regions
Transmission and catabolism of IgG
The structural context of antibody diversity
Monoclonal antibodies and the mechanisms of hypermutation
Antibody structure prediction and development of humanization strategies
Antibody engineering: improving on natural immunity
Therapeutic antibodies: case study I: prevention of respiratory syncytial virus illness
Therapeutic antibodies: case study II: targeting breast cancer
Antibodies: the therapeutic future.
Show 14 more Contents items
ISBN
9780199646579
0199646570
LCCN
2014944571
OCLC
896838006
Statement on language in description
Princeton University Library aims to describe library materials in a manner that is respectful to the individuals and communities who create, use, and are represented in the collections we manage.
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