The antibody molecule : from antitoxins to therapeutic antibodies / by Anthony R. Rees.

Author
Rees, Anthony R. [Browse]
Format
Book
Language
English
Εdition
First edition.
Published/​Created
Oxford : Oxford University Press, 2015.
Description
xii, 364 pages : illustrations, portraits ; 25 cm.

Availability

Copies in the Library

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Firestone Library - Stacks QR186.7 .R44 2015 Browse related items Request

    Details

    Subject(s)
    Series
    Oxford medical histories [More in this series]
    Summary note
    The Antibody Molecule follows the extraordinary journey of the medics and scientists who shaped the course of medical advances in the field of immunology. One of the oldest of the medical sciences, immunology has a history that has seen chemists, physicists, and biologists alike seeking to unravel the most complex system in the human body outside the brain. This book charts its intriguing history, from the genetic basis of antibody diversity, through the understanding of the mechanism by which the immune system's first line of defence works, to breakthroughs in crystallography and the exploitation of immunoglobulins as therapeutic platforms to treat cancer, inflammation, and allergy. Tracing the developments in molecular immunology in chronological order, Professor Anthony R. Rees presents the historical contexts of the periods in rich detail, bringing them to life with quotes and illustrations. This fascinating book examines the literature of the time, turning points, and controversies. A must read for immunologists and life scientists, as well as historians of science and medicine. Book jacket.
    Bibliographic references
    Includes bibliographical references and index.
    Contents
    • Antibody pre-history: the emergence of empirical immunology
    • Pre-molecular immunology: the dawn of mechanism
    • Structural chemistry: locks, keys, and colloids
    • The foundations of antibody-antigen recognition emerge
    • The cellular reformation
    • The molecular path unfolds
    • Uncovering the origins of antibody diversity
    • Immunoglobulin constant regions
    • Effector functions of constant regions
    • Transmission and catabolism of IgG
    • The structural context of antibody diversity
    • Monoclonal antibodies and the mechanisms of hypermutation
    • Antibody structure prediction and development of humanization strategies
    • Antibody engineering: improving on natural immunity
    • Therapeutic antibodies: case study I: prevention of respiratory syncytial virus illness
    • Therapeutic antibodies: case study II: targeting breast cancer
    • Antibodies: the therapeutic future.
    ISBN
    • 9780199646579
    • 0199646570
    LCCN
    2014944571
    OCLC
    896838006
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